Plasma Amino Acids 2.5 yo ASD

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  • #435

    I posted my son’s ubiome, and would like to share an amino acid panel he had done several months ago (before official diagnosis, but during investigations with a neurologist).

    These results were VERY surprising in light of his diet…my son eats lots of protein, from every source but milk. Breakfast includes eggs and several slices of bacon nearly every day!

    And his total cholesterol came back extremely low as well…I think it was 108 combined. We now give him a cholesterol supplement (along with his eggs and bacon lol). He had been experiencing hand/arm tremors, which subsided immediately with the cholesterol supplementation.

    He has been taking digestive enzymes with his meals for ~6 months now, too…

  • #437

    Looking into this (he will be eligible when he turns 3)…

  • #439

    BTW I only learned about this study from the Arkansas Times article you shared on FB…Why don’t doctors seem aware of this kind of research? It’s become a full time job for me to try to study this stuff & navigate my son’s health crisis, even though I have been taking him to multiple specialists for over 6 months

    Sorry for the rant, and thank you again for sharing your wealth of knowledge. You have no idea how much it means to us.

  • #440

    Keith Bell

    The Ketogenic Diet raises BCAAs, see the first link on this photo:

    I’m not sure if it’s safe to give a young child an amino acid supplement, but looking over the test results it seems he’s low on aromatic and branched-chain AAs. There are a couple supplements on the market with only those AAs. And they’re important for neurotransmitter balance (that’s what the photo exploration on facebook is all about). Here’s one of the products:

    Regarding enzymes, have you considered giving them on empty stomach to help with cleansing of the gut?

  • #441

    Keith Bell

    My point is microbes regulate amino acid levels as they degrade them and produce them . . . and the ketogenic diet can shift flora in the right direction, but so can other low carb diets. Fats shift flora depending on the type of fat.

  • #445

    Keith Bell

    This company makes an amino acid supplement and they state it’s safe for children. See their usage chart here:

    Like anything, be safe and begin with small doses if you decide to try this route . . .

  • #446

    Thanks, Keith – I’ll look into the possibility of adding that one.

    Your earlier post about microbes regulating amino acids got me thinking about whether I should supplement them or not, though…if I’m understanding this correctly, it could end up feeding the bad guys, right?

    There is a table on the attached file listing amino acid usage for a few species of thalassospira, and it looks like there could be a connection. This might be part of the reason why some of his aminos are so low even with a very healthy diet…unless it is a matter of protein digestion (or a combination of the two)…

    I don’t know which species he has, because ubiome isn’t that specific. But your earlier point about vancomycin not being effective appears to have been proven for at least one of the species!

    I am now thinking neomycin and possibly flagl…

    Thanks again!!

  • #449

    Oops I meant strains not species…sorry if my non-scientific language is confusing!

  • #456


    1. 316-4.pdf
  • #458

    Keith Bell

    Have you looked into Rifaximin as mentioned in the other thread? I’ve read it’s effective with gram-negative bacteria and helps to raise the good guys, working only in the gut. Maybe a strategy including probiotics and certain prebiotics, possibly phage therapy, etc. along with Rifaximin will help turn the tide . . . along with a low carb diet until things get more balanced . . .

    It’s gonna take much more than antibiotics.

    You can’t kill your way to good health. Add life.™

  • #459

    I did see the rifaximin suggestion, but I haven’t yet found if that one has been tested on thilassospira, whereas neomycin was shown to be effective. I’m still trying to get my mind around phage, and will look into that further. Currently, our plan is still to do antibiotics followed by FMT…

  • #466

    Follow up:

    My son’s amino acids were tested again this week, and we’ve made a huge jump toward normalcy. Perhaps the 3 months of strict SCD have improved his digestion considerably? We have also been supplementing some nutrients, but no amino acids aside from what is in his ANRC Essentisls multivitamin, and some occasional l-carnosine & l-glutamine. We will drop the carnosine now.

    On another note, I believe we will follow your suggestion of Rifaximin to address the proteobacterial overgrowth. We discussed the possible side effects of Neomycin with his doctor, and it’s just too much risk for such a young child.

  • #484

    Keith Bell

    I wonder if it’s possible to avoid use of any antibiotic and shift flora via prebiotics and probiotics.

    Been learning new things about amino acid transport to the brain and just added a few links to the exploration photo on Facebook. It seems leucine may be key to reducing glutamate in the brain which is converted from glutamine. So, even though glutamine is good for the gut you may want to be careful about adding glutamine in supplement form. Leucine and the other BCAAs may be a better route.

    Before learning about this I was focused on how amino acids compete with tryptophan to stabilize serotonin which affects the glutamatergic system, but this other view suggests a more direct route to stabilzing glutamate excitotoxicity. Who knows, perhaps both happen simultaneously.

    The main point is gut flora regulate amino acid levels, not a common view, but there’s plenty of evidence.

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