Gene-microbe interaction and autoimmunity

[Keith BellKeymaster]

There’s so much to learn about gene-microbe interaction as root cause of autoimmunity.

I’ve barely scratched the surface. This is why everyone needs to join forces to understand this complex science. Genetic regulation of microbial populations is another underrated factor, i.e., fucose and the field of glycobiology. There’s also evidence of the immune system selecting Clostridia.

And to think this may be initiated in the fetal GI tract is a paradigm shift most scientists still refuse to accept. It’s time to take them to task.

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid
http://www.nature.com/articles/srep23129

[Keith BellKeymaster]

This may be a landmark paper describing how the immune system first attacks the gut, then the brain in MS including discussion of gut microbiota initiating the process in Peyer’s patches:
Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106335
https://www.sciencedaily.com/releases/2014/09/140904084603.htm

A blog about the paper:
Which comes first: the leaky gut or the dysfunctional immune system?

Which comes first: the leaky gut or the dysfunctional immune system?

An article I’ve written exploring the issue citing the MS study, but not much on autoimmunity:
VACCINE INJURY: First the Gut, Then the Brain
http://www.greenmedinfo.com/blog/vaccine-injury-first-gut-then-brain

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